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Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus
Joint Authors
Wang, Ning-Chi
Sytwu, Huey-Kang
Chuang, Yi-Ping
Chang, Deh-Ming
Wang, Chih-Hung
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with complex immunological and clinical manifestations.
Multiple organ failure in SLE can be caused by immune dysfunction and deposition of autoantibodies.
Studies of SLE-susceptible loci and the cellular and humoral immune responses reveal variable aberrations associated with this systemic disease.
Invariant natural killer T (iNKT) cells are a unique subset of lymphocytes that control peripheral tolerance.
Mounting evidence showing reductions in the proportion and activity of iNKT cells in SLE patients suggests the suppressive role of iNKT cells.
Studies using murine lupus models demonstrate that iNKT cells participate in SLE progression by sensing apoptotic cells, regulating immunoglobulin production, and altering the cytokine profile upon activation.
However, the dichotomy of iNKT cell actions in murine models implies complicated interactions within the body's milieu.
Therefore, application of potential therapy for SLE using glycolipids to regulate iNKT cells should be undertaken cautiously.
American Psychological Association (APA)
Chuang, Yi-Ping& Wang, Chih-Hung& Wang, Ning-Chi& Chang, Deh-Ming& Sytwu, Huey-Kang. 2012. Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-474719
Modern Language Association (MLA)
Chuang, Yi-Ping…[et al.]. Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus. Clinical and Developmental Immunology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-474719
American Medical Association (AMA)
Chuang, Yi-Ping& Wang, Chih-Hung& Wang, Ning-Chi& Chang, Deh-Ming& Sytwu, Huey-Kang. Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-474719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474719