Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia Virus Type 1- (HTLV-1-)Associated MyelopathyTropical Spastic Paraparesis (HAMTSP)
Author
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Human T-cell leukemia virus type 1 (HTLV-1) is a replication-competent human retrovirus associated with two distinct types of disease only in a minority of infected individuals: the malignancy known as adult T-cell leukemia (ATL) and a chronic inflammatory central nervous system disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Although the factors that cause these different manifestations of HTLV-1 infection are not fully understood, accumulating evidence suggests that complex virus-host interactions play an important role in determining the risk of HAM/TSP.
This review focuses on the role of the immune response in controlling or limiting viral persistence in HAM/TSP patients, and the reason why some HTLV-1-infected people develop HAM/TSP whereas the majority remains asymptomatic carriers of the virus.
American Psychological Association (APA)
Saito, Mineki. 2010. Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia Virus Type 1- (HTLV-1-)Associated MyelopathyTropical Spastic Paraparesis (HAMTSP). Interdisciplinary Perspectives on Infectious Diseases،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-474722
Modern Language Association (MLA)
Saito, Mineki. Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia Virus Type 1- (HTLV-1-)Associated MyelopathyTropical Spastic Paraparesis (HAMTSP). Interdisciplinary Perspectives on Infectious Diseases No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-474722
American Medical Association (AMA)
Saito, Mineki. Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia Virus Type 1- (HTLV-1-)Associated MyelopathyTropical Spastic Paraparesis (HAMTSP). Interdisciplinary Perspectives on Infectious Diseases. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-474722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474722