Synthesis and Biological Evaluation of New N,N′-Bis(1-substituted-ethylidene)-ethane1,2-diamine and Their Acetyl and Trifluoroacetyl Derivatives as Cytotoxic and Antimicrobial Agents
Joint Authors
Asiri, Abdullah M.
Faidallah, Hassan M.
Khan, Khalid Ali
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several Schiff bases 2 have been prepared by the condensation of various methyl ketones 1 with 1,2-ethylenediamine.
Subsequent acylation of these Schiff bases with trifluoroacetic anhydride in THF yields the corresponding trifluoroacetyl derivatives 3.
However, o-hydroxy- and o-methoxy-substituted derivatives yielded substituted-trifluoromethylchroman-4-ones.
Additionally, Schiff bases when reacted with acetic anhydride afforded the C-acetylated derivatives 4.
The structures of the isolated compounds were fully determined by spectral methods.
Preliminary biological screening of the prepared compounds revealed significant cytotoxic and antimicrobial activities.
American Psychological Association (APA)
Khan, Khalid Ali& Faidallah, Hassan M.& Asiri, Abdullah M.. 2013. Synthesis and Biological Evaluation of New N,N′-Bis(1-substituted-ethylidene)-ethane1,2-diamine and Their Acetyl and Trifluoroacetyl Derivatives as Cytotoxic and Antimicrobial Agents. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-474742
Modern Language Association (MLA)
Khan, Khalid Ali…[et al.]. Synthesis and Biological Evaluation of New N,N′-Bis(1-substituted-ethylidene)-ethane1,2-diamine and Their Acetyl and Trifluoroacetyl Derivatives as Cytotoxic and Antimicrobial Agents. Journal of Chemistry No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-474742
American Medical Association (AMA)
Khan, Khalid Ali& Faidallah, Hassan M.& Asiri, Abdullah M.. Synthesis and Biological Evaluation of New N,N′-Bis(1-substituted-ethylidene)-ethane1,2-diamine and Their Acetyl and Trifluoroacetyl Derivatives as Cytotoxic and Antimicrobial Agents. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-474742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474742