Genetic Markers of Polycystic Ovary Syndrome : Emphasis on Insulin Resistance
Joint Authors
Mukherjee, Srabani
Dadachanji, Roshan
Shaikh, Nuzhat
Source
International Journal of Medical Genetics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of childbearing age causing not only reproductive but also metabolic anomalies.
PCOS women present with ovulatory dysfunction, abnormal hormones, hyperandrogenemia, obesity, and hyperinsulinemia.
It is a heterogeneous disorder which results from interaction of multiple genes along with environmental factors.
Insulin resistance is a central key element contributing to PCOS pathogenesis and is further aggravated by obesity.
Insulin regulates metabolic homeostasis and contributes to ovarian steroidogenesis.
Candidate gene analyses have dissected genes related to insulin secretion and action for their association with PCOS susceptibility.
Although a large number of genomic variants have been shown to be associated with PCOS, no single candidate gene has emerged as a convincing biomarker thus far.
This may be attributed to large amount of heterogeneity observed in this disorder.
This review presents an overview of the polymorphisms in genes related to insulin signaling and their association with PCOS and its related traits.
American Psychological Association (APA)
Shaikh, Nuzhat& Dadachanji, Roshan& Mukherjee, Srabani. 2014. Genetic Markers of Polycystic Ovary Syndrome : Emphasis on Insulin Resistance. International Journal of Medical Genetics،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-474764
Modern Language Association (MLA)
Shaikh, Nuzhat…[et al.]. Genetic Markers of Polycystic Ovary Syndrome : Emphasis on Insulin Resistance. International Journal of Medical Genetics No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-474764
American Medical Association (AMA)
Shaikh, Nuzhat& Dadachanji, Roshan& Mukherjee, Srabani. Genetic Markers of Polycystic Ovary Syndrome : Emphasis on Insulin Resistance. International Journal of Medical Genetics. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-474764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474764