A Possible Anticancer Agent, Type III Interferon, Activates Cell Death Pathways and Produces Antitumor Effects
Joint Authors
Shimada, Hideaki
Kawamura, Kiyoko
Li, Quanhai
Tada, Yuji
Tagawa, Masatoshi
Hiroshima, Kenzo
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Recently identified interleukin-28 and -29 belong to a novel type III interferon (IFN) family, which could have distinct biological properties from type I and II IFNs.
Type I IFNs, IFN-α/β, have been clinically applied for treating a certain kind of malignancies for over 30 years, but a wide range of the adverse effects hampered the further clinical applications.
Type III IFNs, IFN-λs, have similar signaling pathways as IFN-α/β and inhibits proliferation of tumor cells through cell cycle arrest or apoptosis.
Restricted patterns of type III IFN receptor expression in contrast to ubiquitously expressed IFN-α/β receptors suggest that type III IFNs have limited cytotoxicity to normal cells and can be a possible anticancer agent.
In this paper, we summarize the current knowledge on the IFN-λs-mediated tumor cell death and discuss the functional difference between type I and III IFNs.
American Psychological Association (APA)
Tagawa, Masatoshi& Kawamura, Kiyoko& Li, Quanhai& Tada, Yuji& Hiroshima, Kenzo& Shimada, Hideaki. 2011. A Possible Anticancer Agent, Type III Interferon, Activates Cell Death Pathways and Produces Antitumor Effects. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-474766
Modern Language Association (MLA)
Tagawa, Masatoshi…[et al.]. A Possible Anticancer Agent, Type III Interferon, Activates Cell Death Pathways and Produces Antitumor Effects. Clinical and Developmental Immunology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-474766
American Medical Association (AMA)
Tagawa, Masatoshi& Kawamura, Kiyoko& Li, Quanhai& Tada, Yuji& Hiroshima, Kenzo& Shimada, Hideaki. A Possible Anticancer Agent, Type III Interferon, Activates Cell Death Pathways and Produces Antitumor Effects. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-474766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474766