Obscurin Depletion Impairs Organization of Skeletal Muscle in Developing Zebrafish Embryos
Joint Authors
Raeker, Maide Ö.
Russell, Mark W.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
During development, skeletal myoblasts differentiate into myocytes and skeletal myotubes with mature contractile structures that are precisely oriented with respect to surrounding cells and tissues.
Establishment of this highly ordered structure requires reciprocal interactions between the differentiating myocytes and the surrounding extracellular matrix to form correctly positioned and well-organized attachments from the skeletal muscle to the bony skeleton.
Using the developing zebrafish embryo as a model, we examined the relationship between new myofibril assembly and the organization of the membrane domains involved in cell-extracellular matrix interactions.
We determined that depletion of obscurin, a giant muscle protein, resulted in irregular cell morphology and disturbed extracellular matrix organization during skeletal muscle development.
The resulting impairment of myocyte organization was associated with disturbance of the internal architecture of the myocyte suggesting that obscurin participates in organizing the internal structure of the myocyte and translating those structural cues to surrounding cells and tissues.
American Psychological Association (APA)
Raeker, Maide Ö.& Russell, Mark W.. 2011. Obscurin Depletion Impairs Organization of Skeletal Muscle in Developing Zebrafish Embryos. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-474779
Modern Language Association (MLA)
Raeker, Maide Ö.& Russell, Mark W.. Obscurin Depletion Impairs Organization of Skeletal Muscle in Developing Zebrafish Embryos. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-474779
American Medical Association (AMA)
Raeker, Maide Ö.& Russell, Mark W.. Obscurin Depletion Impairs Organization of Skeletal Muscle in Developing Zebrafish Embryos. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-474779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474779