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Deconstructing GSK-3 : The Fine Regulation of Its Activity
Joint Authors
Medina, Miguel
Wandosell, Francisco
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Glycogen synthase kinase-3 (GSK-3) unique position in modulating the function of a diverse series of proteins in combination with its association with a wide variety of human disorders has attracted significant attention to the protein both as a therapeutic target and as a means to understand the molecular basis of these disorders.
GSK-3 is ubiquitously expressed and, unusually, constitutively active in resting, unstimulated cells.
In mammals, GSK-3α and β are each expressed widely at both the RNA and protein levels although some tissues show preferential levels of some of the two proteins.
Neither gene appears to be acutely regulated at the transcriptional level, whereas the proteins are controlled posttranslationally, largely through protein-protein interactions or by posttranslational regulation.
Control of GSK-3 activity thus occurs by complex mechanisms that are each dependent upon specific signalling pathways.
Furthermore, GSK-3 appears to be a cellular nexus, integrating several signalling systems, including several second messengers and a wide selection of cellular stimulants.
This paper will focus on the different ways to control GSK-3 activity (phosphorylation, protein complex formation, truncation, subcellular localization, etc.), the main signalling pathways involved in its control, and its pathological deregulation.
American Psychological Association (APA)
Medina, Miguel& Wandosell, Francisco. 2011. Deconstructing GSK-3 : The Fine Regulation of Its Activity. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-474793
Modern Language Association (MLA)
Medina, Miguel& Wandosell, Francisco. Deconstructing GSK-3 : The Fine Regulation of Its Activity. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-474793
American Medical Association (AMA)
Medina, Miguel& Wandosell, Francisco. Deconstructing GSK-3 : The Fine Regulation of Its Activity. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-474793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474793