![](/images/graphics-bg.png)
β-Thalassemia Mutations among Transfusion-Dependent Thalassemia Major Patients in Northern Iraq
Joint Authors
Nerweiy, Farida F.
Hassan, Kawa M. A.
al-Allawi, Nasir A. S.
Markous, Raji S. D.
Jubrael, Jaladet
Sheikha, Anwar K.
Source
Molecular Biology International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-05
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Molecular defects responsible for β-thalassemias (thal) were investigated among 254 chromosomes from 127 transfusion-dependent unrelated thalassemic patients from two provinces in Northern Iraq.
Among fourteen identified mutations, the seven most common found in 88.2% of the thal chromosomes were: IVS-II-1 (G→A), IVS-I-1 (G→A), codon 8 (-AA), codon 39 (G→T), codon 8/9 (+G), codon 44 (-C), and codon 5 (-CT).
There were some notable differences in frequencies of various mutations in comparison to other Eastern Mediterranean populations, as well as between the two provinces studied.
The latter illustrates the relative heterogeneity of the mutations distribution in Iraq, and the need to screen other areas of the country, to ensure establishing an effective prenatal program.
American Psychological Association (APA)
al-Allawi, Nasir A. S.& Hassan, Kawa M. A.& Sheikha, Anwar K.& Nerweiy, Farida F.& Markous, Raji S. D.& Jubrael, Jaladet. 2010. β-Thalassemia Mutations among Transfusion-Dependent Thalassemia Major Patients in Northern Iraq. Molecular Biology International،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-474800
Modern Language Association (MLA)
al-Allawi, Nasir A. S.…[et al.]. β-Thalassemia Mutations among Transfusion-Dependent Thalassemia Major Patients in Northern Iraq. Molecular Biology International No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-474800
American Medical Association (AMA)
al-Allawi, Nasir A. S.& Hassan, Kawa M. A.& Sheikha, Anwar K.& Nerweiy, Farida F.& Markous, Raji S. D.& Jubrael, Jaladet. β-Thalassemia Mutations among Transfusion-Dependent Thalassemia Major Patients in Northern Iraq. Molecular Biology International. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-474800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474800