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Hesperidin Ameliorates Immobilization-Stress-Induced Behavioral and Biochemical Alterations and Mitochondrial Dysfunction in Mice by Modulating Nitrergic Pathway
Joint Authors
Shylaja, H.
Sandeep Rao, K. S.
Viswanatha, G. L.
Jagadeesh, M.
Santhosh Kumar, V. R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The present study was aimed to evaluate the protective effect of hesperidin against immobilization-stress-induced alterations in biochemical, behavioral, and mitochondrial functions in mice.
In many instances neuroscientists have reported that acute immobilization stress for 6 h resulted in anxiety and impaired locomotor activity due to excess oxidative-nitrergic stress, depletion of antioxidant defense mechanisms, and mitochondrial dysfunction in animals.
In the present study, 6 h of acute immobilization stress had significantly altered the behavioral (anxiety and memory) and biochemical parameters coupled with mitochondrial dysfunction in Swiss albino mice.
Fourteen days of pretreatment with Hesperidin (50 and 100 mg/kg, p.o.) significantly and dose-dependently inhibited the behavioral and biochemical alterations and mitochondrial dysfunction caused by acute immobilization stress.
Furthermore, pre-treatment of l-arginine (50 mg/kg, i.p.), a nitric oxide precursor, reversed the protective effect of Hesperidin (50 and 100 mg/kg) (P<0.05).
In contrast, pretreatment of l-NAME (5 mg/kg, i.p.), a nitric oxide synthase inhibitor, potentiated the protective effect of Hesperidin (P<0.05).
These results suggest the possible involvement of nitrergic pathway in the protective effect Hesperidin against immobilization-stress-induced behavioral, biochemical, and mitochondrial dysfunction in mice.
American Psychological Association (APA)
Viswanatha, G. L.& Shylaja, H.& Sandeep Rao, K. S.& Santhosh Kumar, V. R.& Jagadeesh, M.. 2012. Hesperidin Ameliorates Immobilization-Stress-Induced Behavioral and Biochemical Alterations and Mitochondrial Dysfunction in Mice by Modulating Nitrergic Pathway. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-474825
Modern Language Association (MLA)
Viswanatha, G. L.…[et al.]. Hesperidin Ameliorates Immobilization-Stress-Induced Behavioral and Biochemical Alterations and Mitochondrial Dysfunction in Mice by Modulating Nitrergic Pathway. ISRN Pharmacology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-474825
American Medical Association (AMA)
Viswanatha, G. L.& Shylaja, H.& Sandeep Rao, K. S.& Santhosh Kumar, V. R.& Jagadeesh, M.. Hesperidin Ameliorates Immobilization-Stress-Induced Behavioral and Biochemical Alterations and Mitochondrial Dysfunction in Mice by Modulating Nitrergic Pathway. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-474825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474825