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Is Still's Disease an Autoinflammatory Syndrome?
Joint Authors
Rossi-Semerano, Linda
Koné-Paut, Isabelle
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Systemic juvenile idiopathic arthritis (sJIA), formerly called Still's disease, is officially classified as a subset of juvenile idiopathic arthritis (JIA).
Beside arthritis, it is characterized by prominent systemic features and a marked inflammatory response.
Even if it is still included in the group of juvenile arthritides, sJIA is set apart from all the other forms of JIA.
This disorder has markedly distinct clinical and laboratory features suggesting a different pathogenesis.
sJIA does not show any association with HLA genes or with autoantibodies and is characterised by an uncontrolled activation of phagocytes with hypersecretion of IL-1 and IL-6.
Based on clinical and laboratory features, as well as on new acquisitions on the pathogenesis, it seems evident that sJIA is an autoinflammatory disease related to abnormality in innate immune system.
The new insights on the pathogenesis of sJIA have therefore dramatically changed the approach to treatment, with the development of targeted treatments (anti-IL-1 and anti-IL-6 agents) more effective and safer than earlier medications.
American Psychological Association (APA)
Rossi-Semerano, Linda& Koné-Paut, Isabelle. 2012. Is Still's Disease an Autoinflammatory Syndrome?. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-474884
Modern Language Association (MLA)
Rossi-Semerano, Linda& Koné-Paut, Isabelle. Is Still's Disease an Autoinflammatory Syndrome?. International Journal of Inflammation No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-474884
American Medical Association (AMA)
Rossi-Semerano, Linda& Koné-Paut, Isabelle. Is Still's Disease an Autoinflammatory Syndrome?. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-474884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474884