Increased Urine IgM and IgG2 Levels, Indicating Decreased Glomerular Size Selectivity, Are Not Affected by Dalteparin Therapy in Patients with Type 2 Diabetes
Joint Authors
Eriksson, Jan W.
Kalani, Majid
Jörneskog, Gun
Torffvit, Ole
Brismar, Kerstin
Eliasson, Björn
Apelqvist, Jan
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Fifty-four type 2 diabetic patients with neuroischemic foot ulcers were randomised to treatment with 5000 IU of dalteparin, (n=28), or physiological saline, (n=26), once daily until ulcer healing or for a maximum of 6 months.
Thirty-three patients had normo-, 15 micro-, and 6 macroalbuminuria.
The urinary levels of IgM and IgG2 were elevated in 47 and 50 patients, respectively.
Elevated urinary levels of IgM and IgG2 indicate decreased glomerular size selectivity.
Urine IgM levels were associated with IGF-1/IGFBP-1 and IGFBP-1 levels.
Dalteparin treatment increased urinary levels of glycosaminoglycans (P<0.001) and serum IGFBP-1 (P<0.05) while no significant effects were seen in any of the other studied parameters.
In conclusion, dalteparin therapy in patients with type 2 diabetes had no effects on urinary levels of albumin, IgM, or IgG2 despite significantly increased glycosaminoglycans in urine.
Elevated urinary levels of IgM and IgG2 might be more sensitive markers of renal disease than albuminuria in patients with type 2 diabetes and antihypertensive therapy.
American Psychological Association (APA)
Torffvit, Ole& Kalani, Majid& Apelqvist, Jan& Eliasson, Björn& Eriksson, Jan W.& Brismar, Kerstin…[et al.]. 2012. Increased Urine IgM and IgG2 Levels, Indicating Decreased Glomerular Size Selectivity, Are Not Affected by Dalteparin Therapy in Patients with Type 2 Diabetes. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-474903
Modern Language Association (MLA)
Torffvit, Ole…[et al.]. Increased Urine IgM and IgG2 Levels, Indicating Decreased Glomerular Size Selectivity, Are Not Affected by Dalteparin Therapy in Patients with Type 2 Diabetes. Biochemistry Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-474903
American Medical Association (AMA)
Torffvit, Ole& Kalani, Majid& Apelqvist, Jan& Eliasson, Björn& Eriksson, Jan W.& Brismar, Kerstin…[et al.]. Increased Urine IgM and IgG2 Levels, Indicating Decreased Glomerular Size Selectivity, Are Not Affected by Dalteparin Therapy in Patients with Type 2 Diabetes. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-474903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474903