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Bleomycin-Induced Lung Injury
Joint Authors
Reinert, Tomás
Nunes, Frederico Arthur Pereira
Scheliga, Adriana Alves de Souza
Baldotto, Clarissa Serodio da Rocha
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bleomycin is a chemotherapeutic agent commonly used to treat curable diseases such as germinative tumors and Hodgkin’s lymphoma.
The major limitation of bleomycin therapy is pulmonary toxicity, which can be life threatening in up to 10% of patients receiving the drug.
The mechanism of bleomycin-induced pneumonitis (BIP) involves oxidative damage, relative deficiency of the deactivating enzyme bleomycin hydrolase, genetic susceptibility, and the elaboration of inflammatory cytokines.
Ultimately, BIP can progress to lung fibrosis.
The diagnosis of BIP is established by the combination of systemic symptoms, radiological and histological findings, and respiratory function tests abnormalities, while other disorders should be excluded.
Although the diagnosis and pathophysiology of this disease have been better characterized over the past few years, there is no effective therapy for the disease.
In general, the clinical picture is extremely complex.
A greater understanding of the BIP pathogenesis may lead to the development of new agents capable of preventing or even treating the injury already present.
Physicians who prescribe bleomycin must be aware of the potential pulmonary toxicity, especially in the presence of risk factors.
This review will focus on BIP, mainly regarding recent advances and perspectives in diagnosis and treatment.
American Psychological Association (APA)
Reinert, Tomás& Baldotto, Clarissa Serodio da Rocha& Nunes, Frederico Arthur Pereira& Scheliga, Adriana Alves de Souza. 2013. Bleomycin-Induced Lung Injury. Journal of Cancer Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-474911
Modern Language Association (MLA)
Reinert, Tomás…[et al.]. Bleomycin-Induced Lung Injury. Journal of Cancer Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-474911
American Medical Association (AMA)
Reinert, Tomás& Baldotto, Clarissa Serodio da Rocha& Nunes, Frederico Arthur Pereira& Scheliga, Adriana Alves de Souza. Bleomycin-Induced Lung Injury. Journal of Cancer Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-474911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474911