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Cyclosporine : A Commentary on Brand versus Generic Formulation Exchange
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The evidence for conversion from brand name to generic equivalent cyclosporine is conflicting.
Cyclosporine is a narrow therapeutic-range drug for which small variations in exposure may have severe clinical consequences for transplant patients.
There is currently a lack of comparative outcome data relating to the pharmacokinetics of the reference formulation, Neoral, and generic formulations in transplant recipients.
A major common concern is the potential inability to attain similar trough levels, an issue that can be easily corrected by ongoing therapeutic drug monitoring to ensure that the new steady state falls within an intended target range.
Prospective clinical studies investigating the efficacy and safety of generic formulations in both de novo and long-term transplant patients are also awaited.
Until further evidence is available on the conversion of transplant patients to or between generic formulations of cyclosporine, any transfer to a different cyclosporine formulation should be undertaken with close supervision.
The best available information to date, however, does not support the frequently held but unsubstantiated belief that generic preparations of immunosuppressive drugs are not as effective as brand names or that conversion from brand to generic is associated with significant danger.
This paper attempts to initiate a discussion of these issues.
American Psychological Association (APA)
Singh, A. K.& Narsipur, S. S.. 2011. Cyclosporine : A Commentary on Brand versus Generic Formulation Exchange. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-474919
Modern Language Association (MLA)
Singh, A. K.& Narsipur, S. S.. Cyclosporine : A Commentary on Brand versus Generic Formulation Exchange. Journal of Transplantation No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-474919
American Medical Association (AMA)
Singh, A. K.& Narsipur, S. S.. Cyclosporine : A Commentary on Brand versus Generic Formulation Exchange. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-474919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474919