The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region
Joint Authors
Yoshiura, Kazunori
Simonetti, Arjan W.
Kamintani, Takeshi
Koga, Shoichi
Kitamoto, Erina
Chikui, Toru
Shiraishi, Tomoko
Obara, Makoto
Ohga, Masahiro
Matsuo, Yoshio
Kawano, Shintaro
Nakamura, Katsumasa
Source
International Journal of Dentistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Many researchers have established the utility of the dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in the differential diagnosis in the head and neck region, especially in the salivary gland tumors.
The subjective assessment of the pattern of the time-intensity curve (TIC) or the simple quantification of the TIC, such as the time to peak enhancement (Tpeak) and the wash-out ratio (WR), is commonly used.
Although the semiquantitative evaluations described above have been widely applied, they do not provide information on the underlying pharmacokinetic analysis in tissue.
The quantification of DCE-MRI is preferable; therefore, many compartment model analyses have been proposed.
The Toft and Kermode (TK) model is one of the most popular compartment models, which provide information about the influx forward volume transfer constant from plasma into the extravascular-extracellular space (EES) and the fractional volume of EES per unit volume of tissue is used in many clinical studies.
This paper will introduce the method of pharmacokinetic analysis and also describe the clinical application of this technique in the head and neck region.
American Psychological Association (APA)
Chikui, Toru& Obara, Makoto& Simonetti, Arjan W.& Ohga, Masahiro& Koga, Shoichi& Kawano, Shintaro…[et al.]. 2012. The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region. International Journal of Dentistry،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-474924
Modern Language Association (MLA)
Chikui, Toru…[et al.]. The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region. International Journal of Dentistry No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-474924
American Medical Association (AMA)
Chikui, Toru& Obara, Makoto& Simonetti, Arjan W.& Ohga, Masahiro& Koga, Shoichi& Kawano, Shintaro…[et al.]. The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region. International Journal of Dentistry. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-474924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474924