A Systematic Literature Review of the Association of Lipoprotein(a) and Autoimmune Diseases and Atherosclerosis
Joint Authors
Kassner, U.
Missala, I.
Steinhagen-Thiessen, E.
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To investigate the association of lipoprotein(a) and atherosclerosis-related autoimmune diseases, to provide information on possible pathophysiologic mechanisms, and to give recommendations for Lp(a) determination and therapeutic options.
Methods.
We performed a systematic review of English language citations referring to the keywords “Lp(a)” AND “autoimmune disease” AND “atherosclerosis,” “Lp(a)” AND “immune system” OR “antiphospholipid (Hughes) syndrome (APS)” OR “rheumatoid arthritis” OR “Sjögren’s syndrome” OR “systemic lupus erythematosus” OR “systemic sclerosis” OR “systemic vasculitis” published between 1991 and 2011 using Medline database.
Results.
22 out of 65 found articles were identified as relevant.
Lp(a) association was highest in rheumatoid arthritis (RA), followed by systemic lupus erythematosus (SLE), moderate in APS and lowest in systemic sclerosis (SSc).
There was no association found between Lp(a) and systemic vasculitis or Sjögren’s syndrome.
Conclusion.
Immune reactions are highly relevant in the pathophysiology of atherosclerosis, and patients with specific autoimmune diseases are at high risk for CVD.
Elevated Lp(a) is an important risk factor for premature atherosclerosis and high Lp(a) levels are also associated with autoimmune diseases.
Anti-Lp(a)-antibodies might be a possible explanation.
Therapeutic approaches thus far include niacin, Lp(a)-apheresis, farnesoid x-receptor-agonists, and CETP-inhibitors being currently under investigation.
American Psychological Association (APA)
Missala, I.& Kassner, U.& Steinhagen-Thiessen, E.. 2012. A Systematic Literature Review of the Association of Lipoprotein(a) and Autoimmune Diseases and Atherosclerosis. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-474937
Modern Language Association (MLA)
Missala, I.…[et al.]. A Systematic Literature Review of the Association of Lipoprotein(a) and Autoimmune Diseases and Atherosclerosis. International Journal of Rheumatology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-474937
American Medical Association (AMA)
Missala, I.& Kassner, U.& Steinhagen-Thiessen, E.. A Systematic Literature Review of the Association of Lipoprotein(a) and Autoimmune Diseases and Atherosclerosis. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-474937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474937