Molecular Phenotypes of Unifocal, Multifocal, and Diffuse Invasive Breast Carcinomas
Joint Authors
Tot, Tibor
Gere, Mária
Hellberg, Dan
Lindquist, David
Tarján, Miklós
Pekár, Gyula
Hofmeyer, Syster
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We analyzed the subgross distribution of the invasive component in 875 consecutive cases of breast carcinomas using large-format histology sections and compared the immunophenotype (estrogen and progesterone receptor expression, HER2 overexpression and expression of basal-like markers, CK5/6, CK14, and epidermal growth factor receptor) in unifocal, multifocal, and diffuse tumors.
Histology grade and lymph node status were also analyzed.
Unifocal invasive carcinomas comprised 58.6% (513/875), multifocal invasive carcinomas 36.5% (319/875), and diffuse invasive carcinomas 4.9% (43/875) of the cases.
The proportion of lymph node-positive cases was significantly higher in multifocal and diffuse carcinomas compared to unifocal cancers, but no other statistically significant differences could be verified between these tumor categories.
Histological multifocality and diffuse distribution of the invasive tumor component seem to be negative morphologic prognostic parameters in breast carcinomas, independent of the molecular phenotype.
American Psychological Association (APA)
Tot, Tibor& Pekár, Gyula& Hofmeyer, Syster& Gere, Mária& Tarján, Miklós& Hellberg, Dan…[et al.]. 2010. Molecular Phenotypes of Unifocal, Multifocal, and Diffuse Invasive Breast Carcinomas. Pathology Research International،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-474955
Modern Language Association (MLA)
Tot, Tibor…[et al.]. Molecular Phenotypes of Unifocal, Multifocal, and Diffuse Invasive Breast Carcinomas. Pathology Research International No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-474955
American Medical Association (AMA)
Tot, Tibor& Pekár, Gyula& Hofmeyer, Syster& Gere, Mária& Tarján, Miklós& Hellberg, Dan…[et al.]. Molecular Phenotypes of Unifocal, Multifocal, and Diffuse Invasive Breast Carcinomas. Pathology Research International. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-474955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474955