A Call for the Aggressive Treatment of Oligometastatic and Oligo-Recurrent Non-Small Cell Lung Cancer
Joint Authors
Niibe, Yuzuru
Yoo, David S.
Urbanic, James J.
Patel, Pretesh R.
Salama, Joseph K.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Metastatic non-small cell lung cancer (NSCLC) carries a dismal prognosis.
Clinical evidence suggests the existence of an intermediate, or oligometastatic, state when metastases are limited in number and/or location.
In addition, following initial curative therapy, many patients present with limited metastatic disease, or oligo-recurrence.
Metastasis-directed, anti-cancer therapies may benefit these patients.
A growing evidence-base supports the use of hypofractionated, image-guided radiotherapy (HIGRT) for a variety of malignant conditions including inoperable stage I NSCLC and many metastatic sites.
When surgical resection is not possible, HIGRT offers an effective alternative for local treatment of limited metastatic disease.
Early studies have produced promising results when HIGRT was delivered to all known sites of disease in patients with oligometastatic/oligo-recurrent NSCLC.
In a population of patients formerly considered rapidly terminal, these studies report five year overall survival rates of 13–22%.
HIGRT for metastatic NSCLC warrants further study.
We call for large, intergroup, and even international randomized trials incorporating HIGRT and other metastasis-directed therapies into the treatment of patients with oligometastatic/oligo-recurrent NSCLC.
American Psychological Association (APA)
Patel, Pretesh R.& Yoo, David S.& Niibe, Yuzuru& Urbanic, James J.& Salama, Joseph K.. 2012. A Call for the Aggressive Treatment of Oligometastatic and Oligo-Recurrent Non-Small Cell Lung Cancer. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-474956
Modern Language Association (MLA)
Patel, Pretesh R.…[et al.]. A Call for the Aggressive Treatment of Oligometastatic and Oligo-Recurrent Non-Small Cell Lung Cancer. Pulmonary Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-474956
American Medical Association (AMA)
Patel, Pretesh R.& Yoo, David S.& Niibe, Yuzuru& Urbanic, James J.& Salama, Joseph K.. A Call for the Aggressive Treatment of Oligometastatic and Oligo-Recurrent Non-Small Cell Lung Cancer. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-474956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474956