![](/images/graphics-bg.png)
Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer's Disease
Joint Authors
Bonte, Frederick J.
Kulkarni, Padmakar V.
Arora, Veera
Antich, Peter P.
Roney, Celeste A.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Detecting aggregated amyloid peptides (Aβ plaques) presents targets for developing biomarkers of Alzheimer's disease (AD).
Polymeric n-butyl-2-cyanoacrylate (PBCA) nanoparticles (NPs) were encapsulated with radiolabelled amyloid affinity I125-clioquinol (CQ, 5-chloro-7-iodo-8-hydroxyquinoline) as in vivo probes.
I125-CQ-PBCA NPs crossed the BBB (2.3±0.9 ID/g) (P<.05) in the WT mouse (N = 210), compared to I125-CQ (1.0±0.4 ID/g).
I125-CQ-PBCA NP brain uptake increased in AD transgenic mice (APP/PS1) versus WT (N = 38; 2.54×105±5.31×104 DLU/mm2; versus 1.98×105±2.22×104 DLU/mm2) and in APP/PS1/Tau.
Brain increases were in mice intracranially injected with aggregated Aβ42 peptide (N = 17; 7.19×105±1.25×105 DLU/mm2), versus WT (6.07×105±7.47×104 DLU/mm2).
Storage phosphor imaging and histopathological staining of the plaques, Fe2+ and Cu2+, validated results.
I125-CQ-PBCA NPs have specificity for Aβ in vitro and in vivo and are promising as in vivo SPECT (I123), or PET (I124) amyloid imaging agents.
American Psychological Association (APA)
Roney, Celeste A.& Arora, Veera& Kulkarni, Padmakar V.& Antich, Peter P.& Bonte, Frederick J.. 2010. Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-474966
Modern Language Association (MLA)
Roney, Celeste A.…[et al.]. Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-474966
American Medical Association (AMA)
Roney, Celeste A.& Arora, Veera& Kulkarni, Padmakar V.& Antich, Peter P.& Bonte, Frederick J.. Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-474966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474966