Integrity of the Anterior Visual Pathway and Its Association with Ambulatory Performance in Multiple Sclerosis
Joint Authors
Pula, John H.
Sandroff, Brian M.
Motl, Robert W.
Balantrapu, Swathi
Source
Multiple Sclerosis International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Retinal nerve fiber layer thickness (RNFLT) and total macular volume (TMV) represent markers of neuroaxonal degeneration within the anterior visual pathway that might correlate with ambulation in persons with multiple sclerosis (MS).
Objective.
This study examined the associations between RNFLT and TMV with ambulatory parameters in MS.
Methods.
Fifty-eight MS patients underwent a neurological examination for generation of an expanded disability status scale (EDSS) score and measurement of RNFLT and TMV using optical coherence tomography (OCT).
Participants completed the 6-minute walk (6MW) and the timed 25-foot walk (T25FW).
The associations were examined using generalized estimating equation models that accounted for within-patient, inter-eye correlations, and controlled for disease duration, EDSS score, and age.
Results.
RNFLT was not significantly associated with 6MW (P=0.99) or T25FW (P=0.57).
TMV was significantly associated with 6MW (P=0.023) and T25FW (P=0.005).
The coefficients indicated that unit differences in 6MW (100 feet) and T25FW (1 second) were associated with 0.040 and −0.048 unit differences in TMV (mm3), respectively.
Conclusion.
Integrity of the anterior visual pathway, particularly TMV, might represent a noninvasive measure of neuroaxonal degeneration that is correlated with ambulatory function in MS.
American Psychological Association (APA)
Balantrapu, Swathi& Sandroff, Brian M.& Pula, John H.& Motl, Robert W.. 2013. Integrity of the Anterior Visual Pathway and Its Association with Ambulatory Performance in Multiple Sclerosis. Multiple Sclerosis International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-474967
Modern Language Association (MLA)
Balantrapu, Swathi…[et al.]. Integrity of the Anterior Visual Pathway and Its Association with Ambulatory Performance in Multiple Sclerosis. Multiple Sclerosis International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-474967
American Medical Association (AMA)
Balantrapu, Swathi& Sandroff, Brian M.& Pula, John H.& Motl, Robert W.. Integrity of the Anterior Visual Pathway and Its Association with Ambulatory Performance in Multiple Sclerosis. Multiple Sclerosis International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-474967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474967