Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis
Joint Authors
Guyomard, Jean-Laurent
Pinel, Jean-François
Massé, Hélène
Charlin, Jean-François
Baudet, Dominique
Edan, Gilles
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-19
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Purpose.
To report favorable outcome of a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) associated with cerebral vasculitis after treatment with immunosuppressive therapy by mitoxantrone.
Design.
Single case report.
Method.
A 22-year-old man presented with acute isolated bilateral loss of vision revealing APMPPE.
Corticosteroid therapy was initiated and visual acuity gradually improved.
Seventeen days later, visual function deteriorated again, associated with flu-like syndrome and severe headaches.
A relapse of APMPPE was diagnosed, complicated with lymphocytic meningitis and cerebral ischemia.
Intravenous therapy with mitoxantrone was performed in combination with methylprednisolone.
Results.
Headaches disappeared in a few days whereas visual acuity gradually improved and stabilized at 20/40 in the right eye and 20/32 in the left eye.
No adverse event was observed.
Clinical improvement was confirmed by magnetic resonance imaging.
Conclusion.
Cerebral vasculitis is the most severe complication of the extraocular manifestations of APMPEE.
This diagnosis should be evoked when severe headaches or behavior disorder are associated with APMPEE.
American Psychological Association (APA)
Massé, Hélène& Guyomard, Jean-Laurent& Baudet, Dominique& Pinel, Jean-François& Edan, Gilles& Charlin, Jean-François. 2009. Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis. Case Reports in Medicine،Vol. 2009, no. 2009, pp.1-3.
https://search.emarefa.net/detail/BIM-475009
Modern Language Association (MLA)
Massé, Hélène…[et al.]. Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis. Case Reports in Medicine No. 2009 (2009), pp.1-3.
https://search.emarefa.net/detail/BIM-475009
American Medical Association (AMA)
Massé, Hélène& Guyomard, Jean-Laurent& Baudet, Dominique& Pinel, Jean-François& Edan, Gilles& Charlin, Jean-François. Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis. Case Reports in Medicine. 2009. Vol. 2009, no. 2009, pp.1-3.
https://search.emarefa.net/detail/BIM-475009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475009