![](/images/graphics-bg.png)
Prophylactic and Therapeutic Breast Conservation in BRCA12 Mutation Carriers
Joint Authors
Williams, Tesha L.
Marshall, Megan L.
Croshaw, Randal L.
Erb, Kathleen M.
Julian, Thomas B.
Source
International Journal of Breast Cancer
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Breast-conserving therapy (BCT) for sporadic breast cancer has been widely accepted by surgeons and patients alike.
While BCT is associated with a higher risk of ipsilateral breast tumor recurrence (IBTR), it has not been shown to decrease overall survival (OS) in comparison with mastectomy.
Many women with a BRCA1/2 mutation opt for mastectomy instead of breast-conserving measures at the time of a breast cancer diagnosis.
In some cases, this is due to fear of aggressive disease, but to date, there have been no studies offering strong evidence that breast conservation should not be offered to these women.
BRCA1/2-associated breast cancer has not been found to be more aggressive or resistant to treatment than comparable sporadic tumors, and no study has shown an actual survival advantage for mastectomy in appropriately treated affected mutation carriers.
This paper reviews the available literature for breast conservation and surgical decision making in BRCA1/2 mutation carriers.
American Psychological Association (APA)
Croshaw, Randal L.& Marshall, Megan L.& Williams, Tesha L.& Erb, Kathleen M.& Julian, Thomas B.. 2011. Prophylactic and Therapeutic Breast Conservation in BRCA12 Mutation Carriers. International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475015
Modern Language Association (MLA)
Croshaw, Randal L.…[et al.]. Prophylactic and Therapeutic Breast Conservation in BRCA12 Mutation Carriers. International Journal of Breast Cancer No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-475015
American Medical Association (AMA)
Croshaw, Randal L.& Marshall, Megan L.& Williams, Tesha L.& Erb, Kathleen M.& Julian, Thomas B.. Prophylactic and Therapeutic Breast Conservation in BRCA12 Mutation Carriers. International Journal of Breast Cancer. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475015