Targeting the Fanconi Anemia Pathway to Identify Tailored Anticancer Therapeutics
Joint Authors
Jenkins, Chelsea
Kan, Jenny
Hoatlin, Maureen E.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The Fanconi Anemia (FA) pathway consists of proteins involved in repairing DNA damage, including interstrand cross-links (ICLs).
The pathway contains an upstream multiprotein core complex that mediates the monoubiquitylation of the FANCD2 and FANCI heterodimer, and a downstream pathway that converges with a larger network of proteins with roles in homologous recombination and other DNA repair pathways.
Selective killing of cancer cells with an intact FA pathway but deficient in certain other DNA repair pathways is an emerging approach to tailored cancer therapy.
Inhibiting the FA pathway becomes selectively lethal when certain repair genes are defective, such as the checkpoint kinase ATM.
Inhibiting the FA pathway in ATM deficient cells can be achieved with small molecule inhibitors, suggesting that new cancer therapeutics could be developed by identifying FA pathway inhibitors to treat cancers that contain defects that are synthetic lethal with FA.
American Psychological Association (APA)
Jenkins, Chelsea& Kan, Jenny& Hoatlin, Maureen E.. 2012. Targeting the Fanconi Anemia Pathway to Identify Tailored Anticancer Therapeutics. Anemia،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-475020
Modern Language Association (MLA)
Jenkins, Chelsea…[et al.]. Targeting the Fanconi Anemia Pathway to Identify Tailored Anticancer Therapeutics. Anemia No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-475020
American Medical Association (AMA)
Jenkins, Chelsea& Kan, Jenny& Hoatlin, Maureen E.. Targeting the Fanconi Anemia Pathway to Identify Tailored Anticancer Therapeutics. Anemia. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-475020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475020