Pepsinogen II Can Be a Potential Surrogate Marker of Morphological Changes in Corpus before and after H. pylori Eradication
Joint Authors
Rakhshani, Naser
Massarrat, Sadegh
Stolte, Manfred
Aliasgari, Ali
Haj-Sheykholeslami, Arghavan
Shahidi, Seyed Mehdi
Zendehdel, Nasrin
Mohamadkhani, Ashraf
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The aim of this investigation is to study the relationship between gastric morphology and serum biomarkers before and after Helicobacter pylori eradication.
Methods.
First-degree relatives of gastric cancer patients underwent gastroscopy before and 2.5 years after H.
pylori eradication.
The morphological changes in two categories (normal to mild and moderate to severe) were compared with level of pepsinogens I and II before eradication (n=369), after eradication (n=115), and in those with persistent infection (n=250).
Results: After eradication, pepsinogen I decreased to 70% and pepsinogen II to 45% of the previous values.
Unlike pepsinogen II and pepsinogen I to II ratio that were affected by the severity of inflammation and atrophy in corpus in all groups, pepsinogen I generally did not change.
After eradication, subjects with high mononuclear infiltration in corpus had lower pepsinogen I (54 versus 77.1 μ/mL), higher pepsinogen II (9.4 versus 6.9 μ/mL), and lower ratio (7.9 versus 11.6) than those without (P<0.05).
Conclusion.
Pepsinogen II is a good marker of corpus morphological changes before and after H.
pylori eradication.
American Psychological Association (APA)
Massarrat, Sadegh& Haj-Sheykholeslami, Arghavan& Mohamadkhani, Ashraf& Zendehdel, Nasrin& Aliasgari, Ali& Rakhshani, Naser…[et al.]. 2014. Pepsinogen II Can Be a Potential Surrogate Marker of Morphological Changes in Corpus before and after H. pylori Eradication. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-475023
Modern Language Association (MLA)
Massarrat, Sadegh…[et al.]. Pepsinogen II Can Be a Potential Surrogate Marker of Morphological Changes in Corpus before and after H. pylori Eradication. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-475023
American Medical Association (AMA)
Massarrat, Sadegh& Haj-Sheykholeslami, Arghavan& Mohamadkhani, Ashraf& Zendehdel, Nasrin& Aliasgari, Ali& Rakhshani, Naser…[et al.]. Pepsinogen II Can Be a Potential Surrogate Marker of Morphological Changes in Corpus before and after H. pylori Eradication. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-475023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475023