Low-Dose, Ionizing Radiation and Age-Related Changes in Skeletal Microarchitecture
Joint Authors
Wang, Angela
Alwood, Joshua S.
Kumar, Akhilesh
Globus, Ruth K.
Limoli, Charles L.
Tran, Luan H.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Osteoporosis can profoundly affect the aged as a consequence of progressive bone loss; high-dose ionizing radiation can cause similar changes, although less is known about lower doses (≤100 cGy).
We hypothesized that exposure to relatively low doses of gamma radiation accelerates structural changes characteristic of skeletal aging.
Mice (C57BL/6J-10 wk old, male) were irradiated (total body; 0-sham, 1, 10 or 100 cGy 137Cs) and tissues harvested on the day of irradiation, 1 or 4 months later.
Microcomputed tomography was used to quantify microarchitecture of high turnover, cancellous bone.
Irradiation at 100 cGy caused transient microarchitectural changes over one month that were only evident at longer times in controls (4 months).
Ex vivo bone cell differentiation from the marrow was unaffected by gamma radiation.
In conclusion, acute ionizing gamma irradiation at 100 cGy (but not at 1 cGy or 10 cGy) exacerbated microarchitectural changes normally found during progressive, postpubertal aging prior to the onset of age-related osteoporosis.
American Psychological Association (APA)
Alwood, Joshua S.& Kumar, Akhilesh& Tran, Luan H.& Wang, Angela& Limoli, Charles L.& Globus, Ruth K.. 2012. Low-Dose, Ionizing Radiation and Age-Related Changes in Skeletal Microarchitecture. Journal of Aging Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-475058
Modern Language Association (MLA)
Alwood, Joshua S.…[et al.]. Low-Dose, Ionizing Radiation and Age-Related Changes in Skeletal Microarchitecture. Journal of Aging Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-475058
American Medical Association (AMA)
Alwood, Joshua S.& Kumar, Akhilesh& Tran, Luan H.& Wang, Angela& Limoli, Charles L.& Globus, Ruth K.. Low-Dose, Ionizing Radiation and Age-Related Changes in Skeletal Microarchitecture. Journal of Aging Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-475058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475058