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Effective Components of Panax quinquefolius and Corydalis tuber Protect Myocardium through Attenuating Oxidative Stress and Endoplasmic Reticulum Stress
Joint Authors
Shi, Da-Zhuo
Xue, Mei
Yang, Lin
Liu, Meilin
Yin, Hui-jun
Miao, Yu
Zhu, Xinyuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Both oxidative stress and endoplasmic reticulum stress (ERS) have been implicated in carcinogenesis and neurological diseases, while there are few reports about the mechanisms of them in the progression of acute myocardial infarction (AMI).
This study examined oxidative stress and ERS in a rat model of AMI and evaluated their role in therapy by metoprolol and effective components of Panax quinquefolius and Corydalis tuber (EPC).
In the present study a rat model of AMI was established by ligation of the left anterior descending coronary artery.
After oral administration of metoprolol or low-to-high doses of EPC for 2 weeks, serum malondialdehyde (MDA), superoxide dismutase (SOD), and 8-iso-prostaglandin F2α (8-iso-PGF2α) were detected using enzyme-linked immunosorbent assay (ELISA).
Quantitative real-time PCR and Western blotting were used to examine mRNA and protein expressions of the hallmarks of ERS-glucose-regulated protein-78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP).
We confirmed that both metoprolol and moderate-to-high dose of EPC decreased 8-iso-PGF2α serum level and downregulated the mRNA and protein expressions of GRP78 and CHOP in myocardium, while EPC also increased SOD serum level.
These results indicated that metoprolol and EPC protect the myocardium by attenuating oxidative stress and ERS induced by myocardial infarction, highlighting the ERS pathways as potential therapeutic targets for AMI.
American Psychological Association (APA)
Xue, Mei& Liu, Meilin& Zhu, Xinyuan& Yang, Lin& Miao, Yu& Shi, Da-Zhuo…[et al.]. 2013. Effective Components of Panax quinquefolius and Corydalis tuber Protect Myocardium through Attenuating Oxidative Stress and Endoplasmic Reticulum Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-475087
Modern Language Association (MLA)
Xue, Mei…[et al.]. Effective Components of Panax quinquefolius and Corydalis tuber Protect Myocardium through Attenuating Oxidative Stress and Endoplasmic Reticulum Stress. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-475087
American Medical Association (AMA)
Xue, Mei& Liu, Meilin& Zhu, Xinyuan& Yang, Lin& Miao, Yu& Shi, Da-Zhuo…[et al.]. Effective Components of Panax quinquefolius and Corydalis tuber Protect Myocardium through Attenuating Oxidative Stress and Endoplasmic Reticulum Stress. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-475087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475087