The Etiological Role of Blood-Brain Barrier Dysfunction in Seizure Disorders
Joint Authors
Janigro, Damir
Puvenna, Vikram
Granata, Tiziana
Alexopoulos, Andreas V.
Marchi, Nicola
Tierney, William
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A wind of change characterizes epilepsy research efforts.
The traditional approach, based on a neurocentric view of seizure generation, promoted understanding of the neuronal mechanisms of seizures; this resulted in the development of potent anti-epileptic drugs (AEDs).
The fact that a significant number of individuals with epilepsy still fail to respond to available AEDs restates the need for an alternative approach.
Blood-brain barrier (BBB) dysfunction is an important etiological player in seizure disorders, and combination therapies utilizing an AED in conjunction with a “cerebrovascular” drug could be used to control seizures more effectively than AED therapy alone.
The fact that the BBB plays an etiologic role in other neurological diseases will be discussed in the context of a more “holistic” approach to the patient with epilepsy, where comorbidity variables are also encompassed by drug therapy.
American Psychological Association (APA)
Marchi, Nicola& Tierney, William& Alexopoulos, Andreas V.& Puvenna, Vikram& Granata, Tiziana& Janigro, Damir. 2011. The Etiological Role of Blood-Brain Barrier Dysfunction in Seizure Disorders. Cardiovascular Psychiatry and Neurology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475097
Modern Language Association (MLA)
Marchi, Nicola…[et al.]. The Etiological Role of Blood-Brain Barrier Dysfunction in Seizure Disorders. Cardiovascular Psychiatry and Neurology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-475097
American Medical Association (AMA)
Marchi, Nicola& Tierney, William& Alexopoulos, Andreas V.& Puvenna, Vikram& Granata, Tiziana& Janigro, Damir. The Etiological Role of Blood-Brain Barrier Dysfunction in Seizure Disorders. Cardiovascular Psychiatry and Neurology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475097