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MicroRNA-24 Modulates Aflatoxin B1-Related Hepatocellular Carcinoma Prognosis and Tumorigenesis
Joint Authors
Xia, Qiang
Liu, Yi-Xiao
Xing, Tian-Yu
Wang, Chao
Long, Xi-Dai
Huang, Xiao-Ying
Ma, Yun
Yao, Jin-Guang
Xi, Zhi-Feng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
MicroRNA-24 (miR-24) may be involved in neoplastic process; however, the role of this microRNA in the hepatocellular carcinoma (HCC) related to aflatoxin B1 (AFB1) has not been well elaborated.
Here, we tested miR-24 expression in 207 pathology-diagnosed HCC cases from high AFB1 exposure areas and HCC cells.
We found that miR-24 was upregulated in HCC tumor tissues relative to adjacent noncancerous tissue samples, and that the high expression of miR-24 was significantly correlated with larger tumor size, higher microvessel density, and tumor dedifferentiation.
Additionally, this microRNA overexpression modified the recurrence-free survival (relative hazard ratio [HR], 4.75; 95% confidence interval [CI], 2.66–8.47) and overall survival (HR=3.58, 95% CI = 2.34–5.46) of HCC patients.
Furthermore, we observed some evidence of joint effects between miR-24 and AFB1 exposure on HCC prognosis.
Functionally, miR-24 overexpression progressed tumor cells proliferation, inhibited cell apoptosis, and developed the formation of AFB1-DNA adducts.
These results indicate for the first time that miR-24 may modify AFB1-related HCC prognosis and tumorigenesis.
American Psychological Association (APA)
Liu, Yi-Xiao& Long, Xi-Dai& Xi, Zhi-Feng& Ma, Yun& Huang, Xiao-Ying& Yao, Jin-Guang…[et al.]. 2014. MicroRNA-24 Modulates Aflatoxin B1-Related Hepatocellular Carcinoma Prognosis and Tumorigenesis. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-475148
Modern Language Association (MLA)
Liu, Yi-Xiao…[et al.]. MicroRNA-24 Modulates Aflatoxin B1-Related Hepatocellular Carcinoma Prognosis and Tumorigenesis. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-475148
American Medical Association (AMA)
Liu, Yi-Xiao& Long, Xi-Dai& Xi, Zhi-Feng& Ma, Yun& Huang, Xiao-Ying& Yao, Jin-Guang…[et al.]. MicroRNA-24 Modulates Aflatoxin B1-Related Hepatocellular Carcinoma Prognosis and Tumorigenesis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-475148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475148