Long-Term Stimulation with Electroacupuncture at DU20 and ST36 Rescues Hippocampal Neuron through Attenuating Cerebral Blood Flow in Spontaneously Hypertensive Rats
Joint Authors
Fan, Jing-Yu
Huo, Ze-Jun
Huang, Ping
Zhou, Chang-Man
Han, Jing-Yan
Hao, Hui-Feng
Yang, Lei
Yao, Hai-Jiang
Tian, Gui-Hua
Sun, Kai
Pan, Chun-Shui
He, Ke
Li, Zhi-Gang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study was designed to investigate the effect of long-term electroacupuncture at Baihui (DU20) and Zusanli (ST36) on cerebral microvessels and neurons in CA1 region of hippocampus in spontaneously hypertensive rats (SHR).
A total of 45 male Wistar rats and 45 SHR were randomly grouped, with or without electroacupuncture (EA) at DU20 and ST36, once every other day for a period of 8 weeks.
The mean arterial pressure (MAP) was measured once every 2 weeks.
Cerebral blood flow (CBF) and the number of open microvessels in hippocampal CA1 region were detected by Laser Doppler and immunohistochemistry, respectively.
Nissl staining and Western blotting were performed, respectively, to determine hippocampus morphology and proteins that were implicated in the concerning signaling pathways.
The results showed that the MAP in SHR increased linearly over the observation period and was significantly reduced following electroacupuncture as compared with sham control SHR rats, while no difference was observed in Wistar rats between EA and sham control.
The CBF, learning and memory capacity, and capillary rarefaction of SHR were improved by EA.
The upregulation of angiotensin II type I receptor (AT1R), endothelin receptor (ETAR), and endothelin-1 (ET-1) in SHR rats was attenuated by electroacupuncture, suggesting an implication of AT1R, ETAR, and ET-1 pathway in the effect of EA.
American Psychological Association (APA)
Tian, Gui-Hua& Sun, Kai& Huang, Ping& Zhou, Chang-Man& Yao, Hai-Jiang& Huo, Ze-Jun…[et al.]. 2013. Long-Term Stimulation with Electroacupuncture at DU20 and ST36 Rescues Hippocampal Neuron through Attenuating Cerebral Blood Flow in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-475153
Modern Language Association (MLA)
Tian, Gui-Hua…[et al.]. Long-Term Stimulation with Electroacupuncture at DU20 and ST36 Rescues Hippocampal Neuron through Attenuating Cerebral Blood Flow in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-475153
American Medical Association (AMA)
Tian, Gui-Hua& Sun, Kai& Huang, Ping& Zhou, Chang-Man& Yao, Hai-Jiang& Huo, Ze-Jun…[et al.]. Long-Term Stimulation with Electroacupuncture at DU20 and ST36 Rescues Hippocampal Neuron through Attenuating Cerebral Blood Flow in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-475153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475153