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The Impact of Uterine Radiation on Subsequent Fertility and Pregnancy Outcomes
Joint Authors
Hickey, Martha
Chander, Sarat
Teh, Wan Tinn
Stern, Catharyn
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Future fertility is of paramount importance to younger cancer survivors.
Advances in assisted reproductive technology mean that young women treated with radiation involving the uterus may require clinical guidance regarding whether to attempt a pregnancy themselves.
We performed a review of the literature regarding radiation involving uterus (total body irradiation (TBI) and pelvic radiation), fertility, and pregnancy outcomes to come up with a recommendation for our patients.
Limited evidence suggests lower fecundity and an increased incidence of pregnancy complications after uterine radiation.
Higher radiation doses and direct uterine radiation both significantly increase the risk of an adverse pregnancy outcome.
Uterine radiation doses of <4 Gy do not appear to impair uterine function.
Adult TBI data (usually 12 Gy) suggest pregnancy is possible but with lower fecundity and more complications.
Although there is no clear data indicating the dose of radiation to the uterus, above which a pregnancy would not be sustainable, we suggest patients receiving >45 Gy during adulthood and >25 Gy in childhood be counselled to avoid attempting pregnancy.
There is preliminary evidence that menopausal hormone therapy and a combination of pentoxifylline and tocopherol may improve uterine function following irradiation.
American Psychological Association (APA)
Teh, Wan Tinn& Stern, Catharyn& Chander, Sarat& Hickey, Martha. 2014. The Impact of Uterine Radiation on Subsequent Fertility and Pregnancy Outcomes. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-475155
Modern Language Association (MLA)
Teh, Wan Tinn…[et al.]. The Impact of Uterine Radiation on Subsequent Fertility and Pregnancy Outcomes. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-475155
American Medical Association (AMA)
Teh, Wan Tinn& Stern, Catharyn& Chander, Sarat& Hickey, Martha. The Impact of Uterine Radiation on Subsequent Fertility and Pregnancy Outcomes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-475155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475155