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A Methanol Extract of Brugmansia arborea Affects the Reinforcing and Motor Effects of Morphine and Cocaine in Mice
Joint Authors
Rodríguez-Arias, Marta
Miñarro, José
Daza-Losada, Manuel
Aguilar, María A.
Bracci, Antonio
De Feo, Vincenzo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Previous reports have shown that several of the effects of morphine, including the development of tolerance and physical withdrawal symptoms, are reduced by extracts of Brugmansia arborea (L.) Lagerheim (Solanaceae) (B.
arborea).
In the present study we evaluate the action of the methanol extract of B.
arborea (7.5–60 mg/kg) on the motor and reinforcing effects of morphine (20 and 40 mg/kg) and cocaine (25 mg/kg) using the conditioned place preference (CPP) procedure.
At the doses employed, B.
arborea did not affect motor activity or induce any effect on CPP.
The extract partially counteracted morphine-induced motor activity and completely blocked the CPP induced by 20 mg/kg morphine.
On the other hand, B.
arborea blocked cocaine-induced hyperactivity but did not block cocaine-induced CPP.
Reinstatement of extinguished preference with a priming dose of morphine or cocaine was also inhibited by B.
arborea.
The complex mechanism of action of B.
arborea, which affects the dopaminergic and the cholinergic systems, seems to provide a neurobiological substrate for the effects observed.
Considered as a whole, these results point to B.
arborea as a useful tool for the treatment of morphine or cocaine abuse.
American Psychological Association (APA)
Bracci, Antonio& Daza-Losada, Manuel& Aguilar, María A.& De Feo, Vincenzo& Miñarro, José& Rodríguez-Arias, Marta. 2013. A Methanol Extract of Brugmansia arborea Affects the Reinforcing and Motor Effects of Morphine and Cocaine in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-475158
Modern Language Association (MLA)
Bracci, Antonio…[et al.]. A Methanol Extract of Brugmansia arborea Affects the Reinforcing and Motor Effects of Morphine and Cocaine in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-475158
American Medical Association (AMA)
Bracci, Antonio& Daza-Losada, Manuel& Aguilar, María A.& De Feo, Vincenzo& Miñarro, José& Rodríguez-Arias, Marta. A Methanol Extract of Brugmansia arborea Affects the Reinforcing and Motor Effects of Morphine and Cocaine in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-475158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475158