Development of Anti-VEGF Therapies for Intraocular Use : A Guide for Clinicians
Joint Authors
Sadda, Srinivas R.
Keane, Pearse A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Angiogenesis is the process by which new blood vessels form from existing vessel networks.
In the past three decades, significant progress has been made in our understanding of angiogenesis; progress driven in large part by the increasing realization that blood vessel growth can promote or facilitate disease.
By the early 1990s, it had become clear that the recently discovered “vascular endothelial growth factor” (VEGF) was a powerful mediator of angiogenesis.
As a result, several groups targeted this molecule as a potential mediator of retinal ischemia-induced neovascularization in disorders such as diabetic retinopathy and retinal vein occlusion.
Around this time, it also became clear that increased intraocular VEGF production was not limited to ischemic retinal diseases but was also a feature of choroidal vascular diseases such as neovascular age-related macular degeneration (AMD).
Thus, a new therapeutic era emerged, utilizing VEGF blockade for the management of chorioretinal diseases characterized by vascular hyperpermeability and/or neovascularization.
In this review, we provide a guide for clinicians on the development of anti-VEGF therapies for intraocular use.
American Psychological Association (APA)
Keane, Pearse A.& Sadda, Srinivas R.. 2011. Development of Anti-VEGF Therapies for Intraocular Use : A Guide for Clinicians. Journal of Ophthalmology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-475161
Modern Language Association (MLA)
Keane, Pearse A.& Sadda, Srinivas R.. Development of Anti-VEGF Therapies for Intraocular Use : A Guide for Clinicians. Journal of Ophthalmology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-475161
American Medical Association (AMA)
Keane, Pearse A.& Sadda, Srinivas R.. Development of Anti-VEGF Therapies for Intraocular Use : A Guide for Clinicians. Journal of Ophthalmology. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-475161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475161