Antiangiogenic Therapy for Glioma
Joint Authors
Cea, Valentina
Verpelli, Chiara
Sala, Carlo
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-08
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Currently, antiangiogenic agents are routinely used for the treatment of patients with glioma.
However, despite advances in pharmacological and surgical therapy, glioma remains an incurable disease.
Indeed, the formation of an abnormal tumor vasculature and the invasion of glioma cells along neuronal tracts are proposed to comprise the major factors that are attributed to the therapeutic resistance of these tumors.
The development of curative therapeutic modalities for the treatment of glioma requires further investigation of the molecular mechanisms regulating angiogenesis and invasion.
In this review, we discuss the molecular characteristics of angiogenesis and invasion in human malignant glioma, we present several available drugs that are used or can potentially be utilized for the inhibition of angiogenesis in glioma, and we focus our attention on the key mediators of the molecular mechanisms underlying the resistance of glioma to antiangiogenic therapy.
American Psychological Association (APA)
Cea, Valentina& Sala, Carlo& Verpelli, Chiara. 2012. Antiangiogenic Therapy for Glioma. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-475162
Modern Language Association (MLA)
Cea, Valentina…[et al.]. Antiangiogenic Therapy for Glioma. Journal of Signal Transduction No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-475162
American Medical Association (AMA)
Cea, Valentina& Sala, Carlo& Verpelli, Chiara. Antiangiogenic Therapy for Glioma. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-475162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475162