Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats
Joint Authors
Ranganath Pai Karkala, Sreedhara
Rao Sirasanagandla, Srinivasa
Potu, Bhagath Kumar
Bhat, Kumar M. R.
Source
Advances in Pharmacological Sciences
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Petroleum ether fraction of Cissus quadrangularis (PECQ) impact on the development of osteopenia in type 1 diabetic rat model has been evaluated.
Diabetic rats were treated orally with two doses of PECQ.
Another group of diabetic rats were treated with subcutaneous injection of synthetic human insulin.
The cortical and trabecular bone thickness and bone strength were significantly decreased in diabetic rats.
Treatment with two doses of PECQ significantly prevented these changes in diabetic rats.
However, PECQ treatment (two doses) did not alter the glycemic levels in these diabetic rats.
Increased levels of serum alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP), and hydroxyproline were noted in diabetic rats when compared to normal control rats.
The two doses of PECQ treatment further improved the serum ALP levels and significantly decreased the serum levels of TRAP and hydroxyproline.
The effects of PECQ treatment on histological, biomechanical, and biochemical parameters are comparable to those of insulin.
Since PECQ improves the bone health in hyperglycemic conditions by enhancing the cortical and trabecular bone growth and altering the circulating bone markers, it could be used as an effective therapy against diabetes-associated bone disorders.
American Psychological Association (APA)
Rao Sirasanagandla, Srinivasa& Ranganath Pai Karkala, Sreedhara& Potu, Bhagath Kumar& Bhat, Kumar M. R.. 2014. Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats. Advances in Pharmacological Sciences،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-475164
Modern Language Association (MLA)
Rao Sirasanagandla, Srinivasa…[et al.]. Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats. Advances in Pharmacological Sciences No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-475164
American Medical Association (AMA)
Rao Sirasanagandla, Srinivasa& Ranganath Pai Karkala, Sreedhara& Potu, Bhagath Kumar& Bhat, Kumar M. R.. Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats. Advances in Pharmacological Sciences. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-475164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475164