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Synthesis, Characterization, Theoretical Crystal Structure, and Antibacterial Activities of Some Transition Metal Complexes of the Thiosemicarbazone (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide
Joint Authors
Abdulreazak, Haziem
al-Majedy, Yasmien K.
al-Amiery, Ahmed A.
Abood, Hussain
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Problem Statement.
In Iraq like most third world countries, attempts discovered new antibiotic drugs derived from thiosemicarbazide and its metal complexes and developed the branch of applied in organic chemistry.
Approach.
New (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide (L) was synthesized in a good yield by the reaction of pyrrolidone with thiosemicarbazide.
Co(II), Ni(II), and Cu(II) complexes of (L) were prepared and characterized by FT-IR, UV/visible spectra, 1HNMR, and CHN analyses.
Moreover, charge, bond length, bond angle, twist angle, heat of formation, and steric energy were calculated by using of the ChemOffice program, and the DFT calculations for the complexes were done.
The free ligand and its metal complexes were tested in vitro against several microorganisms (Staphylococcus aurous, E.
coli, Proteus vulgaris, Pseudomonas, and Klebsiella pneumoniae) to assess their antimicrobial properties.
Results.
The study shows that these complexes have octahedral geometry; in addition, it has high activity against tested bacteria.
Conclusion/Recommendations.
Based on the reported results, it may be concluded that ligand acts as bidentate, neutral ligand, coordinating through one of the nitrogen and sulfur atoms.
American Psychological Association (APA)
al-Amiery, Ahmed A.& al-Majedy, Yasmien K.& Abdulreazak, Haziem& Abood, Hussain. 2011. Synthesis, Characterization, Theoretical Crystal Structure, and Antibacterial Activities of Some Transition Metal Complexes of the Thiosemicarbazone (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide. Bioinorganic Chemistry and Applications،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-475170
Modern Language Association (MLA)
al-Amiery, Ahmed A.…[et al.]. Synthesis, Characterization, Theoretical Crystal Structure, and Antibacterial Activities of Some Transition Metal Complexes of the Thiosemicarbazone (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide. Bioinorganic Chemistry and Applications No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-475170
American Medical Association (AMA)
al-Amiery, Ahmed A.& al-Majedy, Yasmien K.& Abdulreazak, Haziem& Abood, Hussain. Synthesis, Characterization, Theoretical Crystal Structure, and Antibacterial Activities of Some Transition Metal Complexes of the Thiosemicarbazone (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide. Bioinorganic Chemistry and Applications. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-475170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475170