The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis : Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa
Joint Authors
Papezova, Hana
Smitka, Kvido
Hill, Martin
Hainer, Vojtech
Vondra, Karel
Nedvidkova, Jara
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-09
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Eating disorders such as anorexia (AN) and bulimia nervosa (BN) are characterized by abnormal eating behavior.
The essential aspect of AN is that the individual refuses to maintain a minimal normal body weight.
The main features of BN are binge eating and inappropriate compensatory methods to prevent weight gain.
The gut-brain-adipose tissue (AT) peptides and neutralizing autoantibodies play an important role in the regulation of eating behavior and growth hormone release.
The mechanisms for controlling food intake involve an interplay between gut, brain, and AT.
Parasympathetic, sympathetic, and serotoninergic systems are required for communication between brain satiety centre, gut, and AT.
These neuronal circuits include neuropeptides ghrelin, neuropeptide Y (NPY), peptide YY (PYY), cholecystokinin (CCK), leptin, putative anorexigen obestatin, monoamines dopamine, norepinephrine (NE), serotonin, and neutralizing autoantibodies.
This extensive and detailed report reviews data that demonstrate that hunger-satiety signals play an important role in the pathogenesis of eating disorders.
Neuroendocrine dysregulations of the AT-gut-brain axis peptides and neutralizing autoantibodies may result in AN and BN.
The circulating autoantibodies can be purified and used as pharmacological tools in AN and BN.
Further research is required to investigate the orexigenic/anorexigenic synthetic analogs and monoclonal antibodies for potential treatment of eating disorders in clinical practice.
American Psychological Association (APA)
Smitka, Kvido& Papezova, Hana& Vondra, Karel& Hill, Martin& Hainer, Vojtech& Nedvidkova, Jara. 2013. The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis : Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-475176
Modern Language Association (MLA)
Smitka, Kvido…[et al.]. The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis : Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa. International Journal of Endocrinology No. 2013 (2013), pp.1-21.
https://search.emarefa.net/detail/BIM-475176
American Medical Association (AMA)
Smitka, Kvido& Papezova, Hana& Vondra, Karel& Hill, Martin& Hainer, Vojtech& Nedvidkova, Jara. The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis : Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-475176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475176