Distribution of Cardiac Stem Cells in the Human Heart
Joint Authors
Mohr, Friedrich-Wilhelm
Adams, Volker
Dhein, Stefan
Woitek, Felix
Garbade, Jens
Linke, Axel
Arsalan, Mani
Walther, Thomas
Barten, Markus J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
The existence of human cardiac stem cells (hCSC) and their regenerative capacity are not fully defined.
The aim of this study was to identify and analyse the distribution of hCSCs by flow cytometry (FCM).
Methods.
Tissue samples from the left ventricle (LV) and the appendages of the right atrium (RA) and left atrium (LA) were taken during cardiac surgery.
Mononuclear cells (MNCs) were isolated, labelled for the stem-cell-marker c-kit and hematopoietic-lineage markers and analysed by FCM.
Results.
HCSCs could be isolated from the RA, LA, and LV without significant quantitative difference between both atria (A) (RA 4.80 ± 1.76% versus LA 4.99 ± 1.69% of isolated MNCs, P=0.922).
The number of hCSCs was significantly higher in both atria compared to the left ventricle (A 4.90 ± 1.29% versus LV 0.62 ± 0.14% of isolated MNCs, P=0.035).
Conclusion.
The atria contain a higher concentration of hCSC than the left ventricle.
HCSCs located in the atria could serve as an endogenous source for heart regeneration.
American Psychological Association (APA)
Arsalan, Mani& Woitek, Felix& Adams, Volker& Linke, Axel& Barten, Markus J.& Dhein, Stefan…[et al.]. 2012. Distribution of Cardiac Stem Cells in the Human Heart. ISRN Cardiology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-475192
Modern Language Association (MLA)
Arsalan, Mani…[et al.]. Distribution of Cardiac Stem Cells in the Human Heart. ISRN Cardiology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-475192
American Medical Association (AMA)
Arsalan, Mani& Woitek, Felix& Adams, Volker& Linke, Axel& Barten, Markus J.& Dhein, Stefan…[et al.]. Distribution of Cardiac Stem Cells in the Human Heart. ISRN Cardiology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-475192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475192