A Two-Study Comparison of Clinical and MRI Markers of Transition from Mild Cognitive Impairment to Alzheimer’s Disease
Joint Authors
Pelton, Gregory H.
Brown, Patrick J.
Stern, Yaakov
Liu, Xinhua
Devanand, D. P.
Huey, Edward D.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A published predictor model in a single-site cohort study (questionable dementia, QD) that contained episodic verbal memory (SRT total recall), informant report of function (FAQ), and MRI measures was tested using logistic regression and ROC analyses with comparable measures in a second multisite cohort study (Alzheimer’s Disease Neuroimaging Initiative, ADNI).
There were 126 patients in QD and 282 patients in ADNI with MCI followed for 3 years.
Within each sample, the differences in AUCs between the statistical models were very similar.
Adding hippocampal and entorhinal cortex volumes to the model containing AVLT/SRT, FAQ, age and MMSE increased the area under the curve (AUC) in ADNI but not QD, with sensitivity increasing by 2% in ADNI and 2% in QD for a fixed specificity of 80%.
Conversely, adding episodic verbal memory (SRT/AVLT) and FAQ to the model containing age, Mini Mental State Exam (MMSE), hippocampal and entorhinal cortex volumes increased the AUC in ADNI and QD, with sensitivity increasing by 17% in ADNI and 10% in QD for 80% specificity.
The predictor models showed similar differences from each other in both studies, supporting independent validation.
MRI hippocampal and entorhinal cortex volumes showed limited added predictive utility to memory and function measures.
American Psychological Association (APA)
Devanand, D. P.& Liu, Xinhua& Brown, Patrick J.& Huey, Edward D.& Stern, Yaakov& Pelton, Gregory H.. 2012. A Two-Study Comparison of Clinical and MRI Markers of Transition from Mild Cognitive Impairment to Alzheimer’s Disease. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475199
Modern Language Association (MLA)
Devanand, D. P.…[et al.]. A Two-Study Comparison of Clinical and MRI Markers of Transition from Mild Cognitive Impairment to Alzheimer’s Disease. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-475199
American Medical Association (AMA)
Devanand, D. P.& Liu, Xinhua& Brown, Patrick J.& Huey, Edward D.& Stern, Yaakov& Pelton, Gregory H.. A Two-Study Comparison of Clinical and MRI Markers of Transition from Mild Cognitive Impairment to Alzheimer’s Disease. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475199