Metabolic Syndrome, Obesity, and Gastrointestinal Cancer
Joint Authors
Kobayashi, Mitsuyoshi
Kobara, Hideki
Nishiyama, Noriko
Fujihara, Shintaro
Masaki, Tsutomu
Oryu, Makoto
Mori, Hirohito
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Metabolic syndrome is a cluster of metabolic abnormalities and is defined as the presence of three or more of the following factors: increased waist circumference, elevated triglycerides, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose.
Obesity, which is accompanied by metabolic dysregulation often manifested in the metabolic syndrome, is an established risk factor for many cancers.
Adipose tissue, particularly visceral fat, is an important metabolic tissue as it secretes systemic factors that alter the immunologic, metabolic, and endocrine milieu and also promotes insulin resistance.
Within the growth-promoting, proinflammatory environment of the obese state, cross-talk between macrophages, adipocytes, and epithelial cells occurs via obesity-associated hormones, adipocytokines, and other mediators that may enhance cancer risk and progression.
This paper synthesizes the evidence on key molecular mechanisms underlying the obesity-cancer link.
American Psychological Association (APA)
Fujihara, Shintaro& Mori, Hirohito& Kobara, Hideki& Nishiyama, Noriko& Kobayashi, Mitsuyoshi& Oryu, Makoto…[et al.]. 2012. Metabolic Syndrome, Obesity, and Gastrointestinal Cancer. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-475218
Modern Language Association (MLA)
Fujihara, Shintaro…[et al.]. Metabolic Syndrome, Obesity, and Gastrointestinal Cancer. Gastroenterology Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-475218
American Medical Association (AMA)
Fujihara, Shintaro& Mori, Hirohito& Kobara, Hideki& Nishiyama, Noriko& Kobayashi, Mitsuyoshi& Oryu, Makoto…[et al.]. Metabolic Syndrome, Obesity, and Gastrointestinal Cancer. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-475218
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475218