Evidence for the Immunosuppressive Potential of Calcineurin Inhibitor-Sparing Regimens in Liver Transplant Recipients with Impaired Renal Function
Joint Authors
Banshodani, Masataka
Tazawa, Hirofumi
Onoe, Takashi
Tashiro, Hirotaka
Basnet, Nabin Bahadur
Tanaka, Yuka
Doskali, Marlen
Igarashi, Yuka
Ohdan, Hideki
Ide, Kentaro
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Patients requiring liver transplantation (LT) frequently experience renal insufficiency (RI), which affects their survival.
Although calcineurin inhibitor-sparing immunosuppressive regimens (CSRs) are well known to prevent RI, the immune state in recipients receiving CSR remains to be intensively investigated.
Among 60 cases of living-donor LT at our institute, 68% of the patients had none to mild RI (non-RI group) and 32% of the patients had moderate to severe RI (RI group).
The RI group received a CSR comprising reduced dose of tacrolimus, methylprednisolone, and mycophenolate mofetil, while the non-RI group received a regimen comprising conventional dose of tacrolimus and methylprednisolone.
One year after LT, the mean estimated glomerular filtration rate (eGFR) in the RI group had significantly improved, although it was still lower than that of the non-RI group.
Serial mixed lymphocyte reaction assays revealed that antidonor T-cell responses were adequately suppressed in both groups.
Thus, we provide evidence that CSR leads to improvement of eGFR after LT in patients with RI, while maintaining an appropriate immunosuppressive state.
American Psychological Association (APA)
Ide, Kentaro& Tanaka, Yuka& Onoe, Takashi& Banshodani, Masataka& Tazawa, Hirofumi& Igarashi, Yuka…[et al.]. 2011. Evidence for the Immunosuppressive Potential of Calcineurin Inhibitor-Sparing Regimens in Liver Transplant Recipients with Impaired Renal Function. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-475231
Modern Language Association (MLA)
Ide, Kentaro…[et al.]. Evidence for the Immunosuppressive Potential of Calcineurin Inhibitor-Sparing Regimens in Liver Transplant Recipients with Impaired Renal Function. Journal of Transplantation No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-475231
American Medical Association (AMA)
Ide, Kentaro& Tanaka, Yuka& Onoe, Takashi& Banshodani, Masataka& Tazawa, Hirofumi& Igarashi, Yuka…[et al.]. Evidence for the Immunosuppressive Potential of Calcineurin Inhibitor-Sparing Regimens in Liver Transplant Recipients with Impaired Renal Function. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-475231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475231