The Effect of Babesia divergens Infection on the Spleen of Mongolian Gerbils
Joint Authors
Dkhil, Muhammad A.
al-Khalifa, Mohamed S.
al-Quraishy, Salih
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Babesiosis is caused by intraerythrocytic protozoan parasites transmitted by ticks and affects a wide range of domestic and wild animals and occasionally humans.
The current study aimed to investigate the effect of B.
divergens infected erythrocytes on spleen histopathology, cell cycle alteration, and the presence of oxidative stress.
Mongolian gerbils were challenged with 5 × 106 Babesia divergens infected erythrocytes.
Parasitemia reached approximately 77% at day 5 postinfection.
Infection also induced injury of the spleen.
This was evidenced with (i) increases in cellular damage of the spleen, (ii) decrease in antioxidant capacity as indicated by decreased glutathione, catalase, and superoxide dismutase levels, (iii) increased production of malondialdehyde and nitric oxide derived products (nitrite/nitrate), and (iv) increased lactic acid dehydrogenase activity and protein carbonyl content in the spleen.
Infection interfered with normal cell cycle of the spleen cells at G0/G1, S, and G2/M phases.
On the basis of the above results it can be hypothesized that B.
divergens infected erythrocytes could alter the spleen histopathology and cause cell cycle alteration and induce oxidative stress in splenic tissue.
American Psychological Association (APA)
Dkhil, Muhammad A.& al-Quraishy, Salih& al-Khalifa, Mohamed S.. 2014. The Effect of Babesia divergens Infection on the Spleen of Mongolian Gerbils. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-475242
Modern Language Association (MLA)
Dkhil, Muhammad A.…[et al.]. The Effect of Babesia divergens Infection on the Spleen of Mongolian Gerbils. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-475242
American Medical Association (AMA)
Dkhil, Muhammad A.& al-Quraishy, Salih& al-Khalifa, Mohamed S.. The Effect of Babesia divergens Infection on the Spleen of Mongolian Gerbils. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-475242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475242