Serum Cytokine Profile by ELISA in Patients with Echinococcal Cysts of the Liver : A Stage-Specific Approach to Assess Their Biological Activity
Joint Authors
Filice, Carlo
Brunetti, Enrico
Tamarozzi, Francesca
Meroni, Valeria
Genco, Francesca
Piccoli, Luca
Tinelli, Carmine
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
To investigate the usefulness of serum cytokine dosage in the clinical management of cystic echinococcosis (CE), we analyzed serum levels of Th1 and Th2 cytokines in patients with hepatic CE in different cyst stages, CE1-2 (active), CE3a-3b (transitional), and CE4-5 (inactive).
Ex vivo assessment of Th1 (IFN-γ) and Th2 (IL-4, IL-13, and IL-10) cytokines in sera was carried out using ELISA.
IL-10 was undetectable in all serum samples of patients and controls, while a few sera contained measurable amounts of IFN-γ, IL-4, and IL-13.
No statistically significant difference was found between the percentages of positive samples for each cytokine and the different groups analyzed (patients/controls, stage, number, location, and size of the cyst, serology, and sex of patients), with the exception of the association of IL-4 and IL-13 with the cyst stage.
Overall, this investigation showed many limits of serum cytokine dosage as a marker of biological activity of echinococcal cysts.
Because of low sensitivity and lack of specificity of this test, we believe that other ways to evaluate ex vivo biological activity of the cysts should be explored.
American Psychological Association (APA)
Piccoli, Luca& Meroni, Valeria& Genco, Francesca& Tamarozzi, Francesca& Tinelli, Carmine& Filice, Carlo…[et al.]. 2012. Serum Cytokine Profile by ELISA in Patients with Echinococcal Cysts of the Liver : A Stage-Specific Approach to Assess Their Biological Activity. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-475251
Modern Language Association (MLA)
Piccoli, Luca…[et al.]. Serum Cytokine Profile by ELISA in Patients with Echinococcal Cysts of the Liver : A Stage-Specific Approach to Assess Their Biological Activity. Clinical and Developmental Immunology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-475251
American Medical Association (AMA)
Piccoli, Luca& Meroni, Valeria& Genco, Francesca& Tamarozzi, Francesca& Tinelli, Carmine& Filice, Carlo…[et al.]. Serum Cytokine Profile by ELISA in Patients with Echinococcal Cysts of the Liver : A Stage-Specific Approach to Assess Their Biological Activity. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-475251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475251