Adenosine A2A Receptor and IL-10 in Peripheral Blood Mononuclear Cells of Patients with Mild Cognitive Impairment
Joint Authors
Ziglioli, Eleonora
Bergamaschini, Luigi
Mastronardi, Luigina
Casè, Alessandra
Arosio, Beatrice
Nicolini, Paola
Gussago, Cristina
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Adenosine suppresses immune responses through the A2A receptor (A2AR).
This study investigated the interleukin 10 (IL-10) genetic profile and the expression of A2AR in peripheral blood mononuclear cells (PBMCs) of patients with mild cognitive impairment (MCI), Alzheimer disease (AD), and age-matched controls to verify, if they may help distinguish different forms of cognitive decline.
We analyzed the IL-10 genotype and the expression of A2AR in 41 subjects with AD, 10 with amnestic MCI (a-MCI), 49 with multiple cognitive domain MCI (mcd-MCI), and 46 controls.
There was a significant linear increase in A2AR mRNA levels and A2AR density from mcd-MCI to a-MCI, with intermediate levels being found in AD.
The IL-10 AA genotype frequency was 67% in a-MCI, 46% in AD, 35% in mcd-MCI, and 20% in controls.
These data suggest that the assessment of the IL-10 genotype and the expression of A2AR in PBMCs may be a valuable means of differentiating between a-MCI and mcd-MCI.
American Psychological Association (APA)
Arosio, Beatrice& Mastronardi, Luigina& Gussago, Cristina& Nicolini, Paola& Casè, Alessandra& Ziglioli, Eleonora…[et al.]. 2011. Adenosine A2A Receptor and IL-10 in Peripheral Blood Mononuclear Cells of Patients with Mild Cognitive Impairment. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-475262
Modern Language Association (MLA)
Arosio, Beatrice…[et al.]. Adenosine A2A Receptor and IL-10 in Peripheral Blood Mononuclear Cells of Patients with Mild Cognitive Impairment. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-475262
American Medical Association (AMA)
Arosio, Beatrice& Mastronardi, Luigina& Gussago, Cristina& Nicolini, Paola& Casè, Alessandra& Ziglioli, Eleonora…[et al.]. Adenosine A2A Receptor and IL-10 in Peripheral Blood Mononuclear Cells of Patients with Mild Cognitive Impairment. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-475262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475262