Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats
Joint Authors
Tsai, Cheng-Chia
Chang, Chen Kuei
Liu, Zhongmin
Chen, Li-Jen
Chan, Paul
Lin, Jia-Wei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study investigated the merit of ginseng in the improvement of heart failure in diabetic rats and the role of peroxisome proliferator-activated receptors δ (PPARδ).
We used streptozotocin-induced diabetic rat (STZ-rat) to screen the effects of ginseng on cardiac performance and PPARδ expression.
Changes of body weight, water intake, and food intake were compared in three groups of age-matched rats; the normal control (Wistar rats) received vehicle, STZ-rats received vehicle and ginseng-treated STZ-rats.
We also determined cardiac performances in addition to blood glucose level in these animals.
The protein levels of PPARδ in hearts were identified using Western blotting analysis.
In STZ-rats, cardiac performances were decreased but the food intake, water intake, and blood glucose were higher than the vehicle-treated control.
After a 7-day treatment of ginseng in STZ-rats, cardiac output was markedly enhanced without changes in diabetic parameters.
This treatment with ginseng also increased the PPARδ expression in hearts of STZ-rats.
The related signal of cardiac contractility, troponin I phosphorylation, was also raised.
Ginseng-induced increasing of cardiac output was reversed by the cotreatment with PPARδ antagonist GSK0660.
Thus, we suggest that ginseng could improve heart failure through the increased PPARδ expression in STZ-rats.
American Psychological Association (APA)
Tsai, Cheng-Chia& Chan, Paul& Chen, Li-Jen& Chang, Chen Kuei& Liu, Zhongmin& Lin, Jia-Wei. 2014. Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-475272
Modern Language Association (MLA)
Tsai, Cheng-Chia…[et al.]. Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-475272
American Medical Association (AMA)
Tsai, Cheng-Chia& Chan, Paul& Chen, Li-Jen& Chang, Chen Kuei& Liu, Zhongmin& Lin, Jia-Wei. Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-475272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475272