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Intraoperative Cerebral Glioma Characterization with Contrast Enhanced Ultrasound
Joint Authors
Saladino, Andrea
Aiani, Luca
Del Bene, Massimiliano
Martegani, Alberto
Prada, Francesco
Legnani, Federico Giuseppe
DiMeco, Francesco
Vetrano, Ignazio Gaspare
Casali, Cecilia
Filippini, Assunta
Solbiati, Luigi
Saini, Marco
Mattei, Luca
Perin, Alessandro
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Contrast enhanced ultrasound (CEUS) is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors.
Nevertheless its intraoperative use for brain tumors visualization has been performed few times, and a thorough characterization of cerebral glioma had never been performed before.
Aim.
To perform the first characterization of cerebral glioma using CEUS and to possibly achieve an intraoperative differentiation of different gliomas.
Methods.
We performed CEUS in an off-label setting in 69 patients undergoing surgery for cerebral glioma.
An intraoperative qualitative analysis was performed comparing iCEUS with B-mode imaging.
A postprocedural semiquantitative analysis was then performed for each case, according to EFSUMB criteria.
Results were related to histopathology.
Results.
We observed different CE patterns: LGG show a mild, dotted CE with diffuse appearance and slower, delayed arterial and venous phase.
HGG have a high CE with a more nodular, nonhomogeneous appearance and fast perfusion patterns.
Conclusion.
Our study characterizes for the first time human brain glioma with CEUS, providing further insight regarding these tumors’ biology.
CEUS is a fast, safe, dynamic, real-time, and economic tool that might be helpful during surgery in differentiating malignant and benign gliomas and refining surgical strategy.
American Psychological Association (APA)
Prada, Francesco& Mattei, Luca& Del Bene, Massimiliano& Aiani, Luca& Saini, Marco& Casali, Cecilia…[et al.]. 2014. Intraoperative Cerebral Glioma Characterization with Contrast Enhanced Ultrasound. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-475277
Modern Language Association (MLA)
Prada, Francesco…[et al.]. Intraoperative Cerebral Glioma Characterization with Contrast Enhanced Ultrasound. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-475277
American Medical Association (AMA)
Prada, Francesco& Mattei, Luca& Del Bene, Massimiliano& Aiani, Luca& Saini, Marco& Casali, Cecilia…[et al.]. Intraoperative Cerebral Glioma Characterization with Contrast Enhanced Ultrasound. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-475277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475277