MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
Joint Authors
Tonon, Maddalena
Bossi, Fleur
Agostinis, Chiara
Radillo, Oriano
Tedesco, Francesco
Masat, Elisa
De Seta, Francesco
Bulla, Roberta
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The spiral arteries undergo physiologic changes during pregnancy, and the failure of this process may lead to a spectrum of pregnancy disorders, including pre-eclampsia.
Our recent data indicate that decidual endothelial cells (DECs), covering the inner side of the spiral arteries, acquire the ability to synthesize C1q, which acts as a link between endovascular trophoblast and DECs favouring the process of vascular remodelling.
In this study, we have shown that sera obtained from pre-eclamptic patients strongly inhibit the interaction between extravillous trophoblast (EVT) and DECs, preventing endovascular invasion of trophoblast cells.
We further demonstrated that mannose-binding lectin (MBL), one of the factor increased in pre-eclamptic patient sera, strongly inhibits the interaction of EVT with C1q interfering with the process of EVT adhesion to and migration through DECs.
These data suggest that the increased level of MBL in pre-eclampsia may contribute to the failure of the endovascular invasion of trophoblast cells.
American Psychological Association (APA)
Agostinis, Chiara& Bossi, Fleur& Masat, Elisa& Radillo, Oriano& Tonon, Maddalena& De Seta, Francesco…[et al.]. 2011. MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-475283
Modern Language Association (MLA)
Agostinis, Chiara…[et al.]. MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia. Clinical and Developmental Immunology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-475283
American Medical Association (AMA)
Agostinis, Chiara& Bossi, Fleur& Masat, Elisa& Radillo, Oriano& Tonon, Maddalena& De Seta, Francesco…[et al.]. MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-475283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475283