![](/images/graphics-bg.png)
Cell Therapy in Chagas Disease
Joint Authors
Soares, Milena Botelho Pereira
Goldenberg, Regina C. S.
Spray, David C.
dos Santos, Ricardo Ribeiro
Tanowitz, Herbert B.
Campos de Carvalho, Antonio C.
Jelicks, Linda A.
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Chagas disease which is caused by the parasite Trypanosoma cruzi is an important cause of cardiomyopathy in Latin America.
In later stages chagasic cardiomyopathy is associated with congestive heart failure which is often refractory to medical therapy.
In these individuals heart transplantation has been attempted.
However, this procedure is fraught with many problems attributable to the surgery and the postsurgical administration of immunosuppressive drugs.
Studies in mice suggest that the transplantation of bone-marrow-derived cells ameliorates the inflammation and fibrosis in the heart associated with this infection.
Cardiac magnetic resonance imaging reveals that bone marrow transplantation ameliorates the infection induced right ventricular enlargement.
On the basis of these animal studies the safety of autologous bone marrow transplantation has been assessed in patients with chagasic end-stage heart disease.
The initial results are encouraging and more studies need to be performed.
American Psychological Association (APA)
Campos de Carvalho, Antonio C.& Goldenberg, Regina C. S.& Jelicks, Linda A.& Soares, Milena Botelho Pereira& dos Santos, Ricardo Ribeiro& Spray, David C.…[et al.]. 2009. Cell Therapy in Chagas Disease. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-475285
Modern Language Association (MLA)
Campos de Carvalho, Antonio C.…[et al.]. Cell Therapy in Chagas Disease. Interdisciplinary Perspectives on Infectious Diseases No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-475285
American Medical Association (AMA)
Campos de Carvalho, Antonio C.& Goldenberg, Regina C. S.& Jelicks, Linda A.& Soares, Milena Botelho Pereira& dos Santos, Ricardo Ribeiro& Spray, David C.…[et al.]. Cell Therapy in Chagas Disease. Interdisciplinary Perspectives on Infectious Diseases. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-475285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475285