TNF and TNF Receptor Superfamily Members in HIV infection : New Cellular Targets for Therapy?
Joint Authors
Herbein, Georges
Abbas, Wasim
Kumar, Amit
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Tumor necrosis factor (TNF) and TNF receptors (TNFR) superfamily members are engaged in diverse cellular phenomena such as cellular proliferation, morphogenesis, apoptosis, inflammation, and immune regulation.
Their role in regulating viral infections has been well documented.
Viruses have evolved with numerous strategies to interfere with TNF-mediated signaling indicating the importance of TNF and TNFR superfamily in viral pathogenesis.
Recent research reports suggest that TNF and TNFRs play an important role in the pathogenesis of HIV.
TNFR signaling modulates HIV replication and HIV proteins interfere with TNF/TNFR pathways.
Since immune activation and inflammation are the hallmark of HIV infection, the use of TNF inhibitors can have significant impact on HIV disease progression.
In this review, we will describe how HIV infection is modulated by signaling mediated through members of TNF and TNFR superfamily and in turn how these latter could be targeted by HIV proteins.
Finally, we will discuss the emerging therapeutics options based on modulation of TNF activity that could ultimately lead to the cure of HIV-infected patients.
American Psychological Association (APA)
Kumar, Amit& Abbas, Wasim& Herbein, Georges. 2013. TNF and TNF Receptor Superfamily Members in HIV infection : New Cellular Targets for Therapy?. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-475289
Modern Language Association (MLA)
Kumar, Amit…[et al.]. TNF and TNF Receptor Superfamily Members in HIV infection : New Cellular Targets for Therapy?. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-475289
American Medical Association (AMA)
Kumar, Amit& Abbas, Wasim& Herbein, Georges. TNF and TNF Receptor Superfamily Members in HIV infection : New Cellular Targets for Therapy?. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-475289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475289