Efficacy of a “Rescue” Ciprofloxacin-Based Regimen for Eradication of Helicobacter pylori Infection after Treatment Failures
Joint Authors
Piana, Andrea
Are, Bianca
Mura, Ida
Dore, Maria Pina
Massarelli, Giovannino
Fanciulli, Giuseppe
Tadeu, Vincenza
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of our study was to evaluate the efficacy and tolerability of a ciprofloxacin-based regimen for H.
pylori eradication failures as an alternative to bismuth based quadruple therapy.
Methods.
Design: prospective single-center study.
Patients in whom a first eradication trial with omeprazole/esomeprazole, clarithromycin plus amoxicillin or tinidazole/metronidazole had failed were included.
H.
pylori status: established by histology, rapide urease test and polymerase chain reaction.
Intervention: esomeprazole 20 mg, ciprofloxacin 500 mg, and metronidazole 500 mg, administered together before breakfast and dinner for 10 days.
Susceptibility testing was performed by the Epsilometer test.
Ciprofloxacin resistance was defined as a MIC of ≥1 μg/mL.
Eradication was established by a negative 13C-UBT and 4–6 weeks post-therapy.
Efficacy and side effects were determined.
Results.
34 patients were enrolled, 32 completed the study.
Compliance was excellent (100%).
Side effects were mild.
Ciprofloxacin-based therapy cured 65% (22/34) of patients by intention to treat and 69% (22/32) per protocol analysis.
The prevalence of ciprofloxacin resistance was 8%.
Conclusions.
The effectiveness of ciprofloxacin-based therapy was greatly reduced despite the high prevalence of ciprofloxacin sensitive H.
pylori strains.
Bismuth based quadruple therapy still remain the best choice as a “rescue” regimen in our region.
American Psychological Association (APA)
Dore, Maria Pina& Tadeu, Vincenza& Are, Bianca& Mura, Ida& Fanciulli, Giuseppe& Massarelli, Giovannino…[et al.]. 2012. Efficacy of a “Rescue” Ciprofloxacin-Based Regimen for Eradication of Helicobacter pylori Infection after Treatment Failures. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-475304
Modern Language Association (MLA)
Dore, Maria Pina…[et al.]. Efficacy of a “Rescue” Ciprofloxacin-Based Regimen for Eradication of Helicobacter pylori Infection after Treatment Failures. Gastroenterology Research and Practice No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-475304
American Medical Association (AMA)
Dore, Maria Pina& Tadeu, Vincenza& Are, Bianca& Mura, Ida& Fanciulli, Giuseppe& Massarelli, Giovannino…[et al.]. Efficacy of a “Rescue” Ciprofloxacin-Based Regimen for Eradication of Helicobacter pylori Infection after Treatment Failures. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-475304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475304