A Quantitative Assessment of Tremor and Ataxia in Female FMR1 Premutation Carriers Using CATSYS
Joint Authors
Brodovsky, Jeffrey
Tassone, Flora
Hagerman, Randi J.
Hagerman, Paul J.
Narcisa, Vivien
Campos, Luis
Adams, Patrick
Nguyen, Danh V.
White, Shana
Aguilar, Dalila
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The fragile X-associated tremor/ataxia syndrome (FXTAS) is a relatively common cause of balance problems leading to gait disturbances in older males (40%) with the premutation.
FXTAS is less common in females.
We utilized the CATSYS system, a quantitative measure of movement, in 23 women with FXTAS (mean age 62.7; SD 12.3), 90 women with the premutation without FXTAS (mean age 52.9; SD 9.4), and 37 controls (mean age 56.53; SD 7.8).
CATSYS distinguished differences between carriers with and without FXTAS in postural tremor, postural sway, hand coordination, and reaction time tasks.
Differences were also seen between carriers without FXTAS and controls in finger tapping, reaction time, and one postural sway task.
However, these differences did not persist after statistical correction for multiple comparisons.
Notably, there were no differences across groups in intention tremor.
This is likely due to the milder symptoms in females compared to males with FXTAS.
American Psychological Association (APA)
Narcisa, Vivien& Aguilar, Dalila& Nguyen, Danh V.& Campos, Luis& Brodovsky, Jeffrey& White, Shana…[et al.]. 2011. A Quantitative Assessment of Tremor and Ataxia in Female FMR1 Premutation Carriers Using CATSYS. Current Gerontology and Geriatrics Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-475318
Modern Language Association (MLA)
Narcisa, Vivien…[et al.]. A Quantitative Assessment of Tremor and Ataxia in Female FMR1 Premutation Carriers Using CATSYS. Current Gerontology and Geriatrics Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-475318
American Medical Association (AMA)
Narcisa, Vivien& Aguilar, Dalila& Nguyen, Danh V.& Campos, Luis& Brodovsky, Jeffrey& White, Shana…[et al.]. A Quantitative Assessment of Tremor and Ataxia in Female FMR1 Premutation Carriers Using CATSYS. Current Gerontology and Geriatrics Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-475318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475318