Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275) with the Susceptibility of Breast Cancer : An Updated Meta-Analysis Involving 34,590 Subjects
Joint Authors
Lin, Shuai
Xu, Dan
Dai, Zhi-Jun
Ren, Hong Tao
Wang, Meng
Ma, Xiao-Bin
Tang, Wei
Kang, Hua-Feng
Wang, Xi-Jing
Shao, Yong-Ping
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several single nucleotide polymorphisms have been identified in cyclooxygenase-2 (COX-2) genes (e.g., −765 G>C (rs20417), −1195G>A (rs689466), and 8473 C>T (rs5275)).
The association of these SNPs with the risk of different cancer types is still controversial.
This study aims to evaluate the correlation between these SNPs and breast cancer risk in different ethnic groups.
We have searched PubMed, Web of Knowledge, and Embase for relevant studies.
Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the associations.
A total of 13 studies (15,330 cases and 19,260 controls) were eligible for meta-analysis.
This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians.
The rs5275 polymorphism had no association with breast cancer risk.
American Psychological Association (APA)
Dai, Zhi-Jun& Shao, Yong-Ping& Ma, Xiao-Bin& Xu, Dan& Tang, Wei& Kang, Hua-Feng…[et al.]. 2014. Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275) with the Susceptibility of Breast Cancer : An Updated Meta-Analysis Involving 34,590 Subjects. Disease Markers،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-475319
Modern Language Association (MLA)
Dai, Zhi-Jun…[et al.]. Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275) with the Susceptibility of Breast Cancer : An Updated Meta-Analysis Involving 34,590 Subjects. Disease Markers No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-475319
American Medical Association (AMA)
Dai, Zhi-Jun& Shao, Yong-Ping& Ma, Xiao-Bin& Xu, Dan& Tang, Wei& Kang, Hua-Feng…[et al.]. Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275) with the Susceptibility of Breast Cancer : An Updated Meta-Analysis Involving 34,590 Subjects. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-475319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475319
